An individual in the pedigree will be affected (express the phenotype associated with a trait) when the individual carries at least one dominant allele of a dominant trait, or two recessive alleles of a recessive a trait. generations are not carriers.
What pedigree only affects males?
In a Y-linked disorder, only males can be affected. If the father is affected all sons will be affected.
What are the characteristics of a dominant pedigree?
Characteristics of autosomal dominant traits: –Every affected person has at least one affected parent. -When the trait (or disease) is rare in the population, shows vertical pattern of inheritance in the pedigree (affected males and females in each generation).
How do you calculate penetrance on a pedigree?
Crude penetrance estimates can be derived by dividing the observed number of diseased (penetrant) individuals by the number of obligate carriers (penetrant as well as obligate non-penetrant, that is, normal individuals with several affected offspring or normal individuals with affected parent and child).